Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation
نویسندگان
چکیده
منابع مشابه
Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation
Nadine Martin, Nikolay Popov, Francesca Aguilo, Ana O’Loghlen, Selina Raguz, Ambrosius P Snijders, Gopuraja Dharmalingam, SiDe Li, Efstathia Thymiakou, Thomas Carroll, Bernd B Zeisig, Chi Wai Eric So, Gordon Peters, Vasso Episkopou, Martin J Walsh and Jesús Gil* Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, London, UK, Epigenetics Section, MRC Clinical Science...
متن کاملInterplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.
The INK4/ARF locus regulates senescence and is frequently altered in cancer. In normal cells, the INK4/ARF locus is found silenced by Polycomb repressive complexes (PRCs). Which are the mechanisms responsible for the recruitment of PRCs to INK4/ARF and their other target genes remains unclear. In a genetic screen for transcription factors regulating senescence, we identified the homeodomain-con...
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The polycomb group (PcG) proteins are a large and diverse family that epigenetically repress the transcription of key developmental genes. They form three broad groups of polycomb repressive complexes (PRCs) known as PRC1, PRC2 and Polycomb Repressive DeUBiquitinase, each of which modifies and/or remodels chromatin by distinct mechanisms that are tuned by having variable compositions of core an...
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Duplicated genes are a major contributor to genome evolution and phenotypic novelty. There are multiple possible evolutionary fates of duplicated genes. Here, we provide an example of concerted divergence of simultaneously duplicated genes whose products function in the same complex. We studied POLYCOMB REPRESSIVE COMPLEX2 (PRC2) in Brassicaceae. The VERNALIZATION (VRN)-PRC2 complex contains VR...
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Polycomb group (PcG) proteins function as chromatin-based transcriptional repressors that are essential for normal gene regulation during development. However, how these systems function to achieve transcriptional regulation remains very poorly understood. Here, we discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the compositio...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2013
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2013.37